Santarus Announces Launch Of ZEGERID Products By GlaxoSmithKline In Puerto Rico And U.S. Virgin Islands Part 2

ZEGERID Capsules and Powder all for Oral Suspension sleeve a mash of omeprazole, a proton pump inhibitor (PPI), and sodium bicarbonate, an antacid, which elevate the gastric pH and by this means mollycoddle the omeprazole from acerbic misery.

ZEGERID products proposition a definite pharmacological profile - fast reaching maximal plasma level (in purely about 30 minutes) and providing compelling acid calmness. While the correlation of pharmacodynamic facts to clinical effect partisan not be advanced, the median percentage of episode gastric pH be greater than 4 ended 24 hours inwardly patients treat beside ZEGERID in a pharmacodynamic cram collection from 12.2 hours to 18.6 hours, depending by the side of the may possibly and dosage profile, after unyielding once-daily dose. ZEGERID can be conveniently taken once-a-day on an forsaken tummy, at smallest sufficient one hour past a feast.

PPIs be widely prescribed for a range of disease and disorder of the upper digestive tract. All now market oral PPIs in the U.S., excluding ZEGERID, are delayed-release formulations that utilize an enteric outer gradation to protect the PPI from acid degradation, thereby delay digestion and first acid suppression. Unlike delayed-release PPIs, ZEGERID Capsules and Powder for Oral Suspension utilize an antacid in lieu of an enteric coating. The antacid neutralize stomach acid and protects the PPI, omeprazole, from gastric acid degradation and allows for its swift absorption and suppression of gastric acid.

Important Safety Information The utmost again and again report adverse measures with ZEGERID are headache, diarrhea, and abdominal afflict. In critically under the weather patients treated with ZEGERID, adverse events mostly reflect the solemn, underlying medical giving out of the patients, and be analogous for patients treated with ZEGERID and with the comparator (acid-controlling) linctus. Symptomatic answer to daze therapy apply not preclude the being in attendance of gastric malignancy. Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated drawn out student house with omeprazole.

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